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Molds and other allergens can arise from a host of means, but there are two common classes: (a) moisture induced growth of mold colonies and (b) natural substances released into the air such as animal dander and plant pollen. Moisture buildup inside buildings may arise from water penetrating compromised areas of the building envelope or skin, from plumbing leaks, from condensation due to improper ventilation, or from ground moisture penetrating a building part. In areas where cellulosic materials (paper and wood, including drywall) become moist and fail to dry within 48 hours, mold mildew can propagate and release allergenic spores into the air. More serious than most allergenic properties is the ability of mold to trigger episodes in persons that already have asthma, a serious respiratory disease.

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